![]() All subjects signed a written informed consent before participating in any the study. Sixty adult epileptic patients were enrolled in this cross-sectional study from Ain Shams University Hospitals, Epilepsy Clinic. ![]() Moreover, antiepileptic drugs can have a diverse effect on sleep architecture and quality in epileptic patients. Patients with refractory epilepsy suffer from more disturbance in sleep patterns. ConclusionĮpilepsy affects sleep architecture and sleep-related events. Respiratory events as light sleep durations, were observed to be higher in Group II, in addition to apnea-hypopnea index that was significantly higher in this group. However, higher arousal index, insomnia, and periodic limb movement index were found to be significantly higher in group I. Patients in group II, had significantly delayed sleep onset latency and REM latency. We excluded any patient with abnormal general or neurological clinical examination. All patients had an overnight polysomnogram and sleep EEG done. Sixty epilepsy patients were included half of them with controlled epilepsy were assigned as group I, and the other half with refractory epilepsy was assigned as group II. We aimed at comparing the sleep disturbances in a group of patients with medically controlled epilepsy versus another group with medically refractory epilepsy, from the electrophysiological standpoint. Patients with epilepsy often complain of poor sleep and on the other hand, poor sleep makes epilepsy control difficult. © Copyright 2011 Physicians Postgraduate Press, Inc.Sleep disorders and epilepsy commonly exist and affect each other. In patients with residual depression and treatment refractory insomnia, adding brief behavioral therapy for insomnia to usual clinical care produced statistically significant and clinically substantive added benefits.Ĭ Identifier: NCT00610259. The combination treatment produced higher rates of remission than TAU alone, both in terms of insomnia (50% vs 0%), with a number needed to treat (NNT) of 2 (95% CI, 1-4), and in terms of depression (50% vs 6%), with an NNT of 2 (95% CI, 1-5). 013) and the GRID-HAMD scores after removing the 3 sleep items (P =. Significant differences were observed in favor of the combination group on both the total GRID-HAMD scores (P =. The sleep efficiency for the combination was also significantly better than that for TAU alone (P =. The patients were recruited from February 18, 2008, to April 9, 2009.īrief behavioral therapy for insomnia plus TAU resulted in significantly lower ISI scores than TAU alone at 8 weeks (P <. The Insomnia Severity Index (ISI) scores (primary outcome), sleep parameters, and GRID-Hamilton Depression Rating Scale (GRID-HAMD) scores were assessed by blind raters and remission rates for both insomnia and depression were collected at 4- and 8-week follow-ups. Thirty-seven outpatients (mean age of 50.5 years) were randomly assigned to TAU alone or TAU plus brief behavioral therapy for insomnia, consisting of 4 weekly 1-hour individual sessions. This study aimed to investigate the added value of brief behavioral therapy for insomnia over treatment as usual (TAU) for residual depression and refractory insomnia. Insomnia often persists despite pharmacotherapy in depression and represents an obstacle to its full remission.
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